Clinical Chemistry Practical Essay Example | Topics and Well Written Essays - 500 words

Clinical Chemistry Practical - Essay Example The supernatant was neutralized with 3.2M K2CO3. After recentrifugation, the glucose fraction was extracted from the second supernatant by rapid sequential anion and cation exchange chromatography . The fraction containing glucose was dried before derivatization . The 297-to-299 ionic ratio responses were calculated in terms of isotopic enrichments using a standard curve made up from a known enrichment of glucose solutions. The diagnosis is diabetic ketoacidosis (DKA). Three key features of diabetic ketoacidosis are hyperglycemia, ketosis, and acidosis. The conditions that cause these metabolic abnormalities overlap. DKA is defined as an increase in the serum concentration of ketones greater than 5 mEq/L, a blood glucose level of greater than 250 mg/dL (although it is usually much higher),blood pH of less than 7.2, and a bicarbonate level of 18 mEq/L or less. DKA usually occurs as a consequence of absolute or relative insulin deficiency that is accompanied by an increase in counter-regulatory hormones (ie, glucagon, cortisol, growth hormone, epinephrine). This type of hormonal imbalance enhances hepatic gluconeogenesis, glycogenolysis, and lipolysis. Hepatic gluconeogenesis, glycogenolysis secondary to insulin deficiency, and counter-regulatory hormone excess result in severe hyperglycemia, while lipolysis increases serum free fatty acids.

Inherent risk Essay Example | Topics and Well Written Essays - 1500 words

Inherent risk - Essay Example The impact of this on the total shareholdings needs to be independently addressed by the auditors. Undervaluation of shares: The management believes that the shares of the Company have been undervalued and hence has reduced the holdings on 30.6.2007 by buying back 5.2.Million Shares valued at $9.3m. (Speciality Fashion Group Annual Report. 2007. P. 8). Its impact on the present holdings needs to be reviewed by auditors. Climatic Risks that impinge upon Co.'s business: It is seen that the Company, which specializes in women's garments has had lowered business trends during the winter months, especially the peak Christmas season. Moreover the various seasonal competitions has also slackened business prospects. Risks associated with the rapport and reliability of key employees: The management functions as a closely knit operational team and decisions are made on consensus. Although the members of the team are highly motivated, committed and dependable, there are always risks of management employees' attrition, for better prospects and higher positions. This could be perceived as an inherent risk in this Company Risks Risks associated with need for strategic growth: The women's garment industry in Australia and New Zealand are the main areas of marketing focus by this Company. There is always a dormant risk that customer preferences and tastes may change, due to conspicuous changes in fashion industry needs and competitive environment, in which the Company operates. Although the Company has designed garment wear for all age groups, income stratas and lifestyles, the inherent risks of a high degree of fashion obsolescence cannot be ruled out, which could affect demand for the products and cost of carrying inventories. Supply Chain Management risks and strategic vendor relationships: The Company presently has 784 locations situated in Australia and New Zealand. (Speciality Fashion Group Annual Report. 2007. P. 10). Many more stores are going to be opened to future to cater to the increasing clientele and it is necessary to have the necessary efficient logistics in place so that all the stores are well stocked with stocks at all times. It is therefore a test for the supply chain management systems in operation to build up efficiency and prompt dispatches and also have excellent vendor network so that goods are speedily replenished and restocked at all locations. The inherent risks arise when, due to failure of the system, ordered supplies are not available on demand, which could reflect upon the reordering systems in vogue.